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Title: Kinetic study of human thymine DNA glycosylase and examination of its interaction with apurinic endonuclease 1 in base excision repair
Author: Abu, M.
Awarding Body: University of London
Current Institution: University College London (University of London)
Date of Award: 2005
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In the human genome, cytosine is exclusively methylated at CpG sequences to give 5-methylcytosine. The C4-amino group of 5-methylcytosine is susceptible to spontaneous hydrolysis, generating thymine in a G T mismatch. Thymine DNA glycosylase (TDG) detects the mismatch and cleaves the glycosidic bond of thymine. Then apyrimidinic/apurinic endonuclease 1 (APEX1) displaces TDG from the abasic site and cuts the phosphodiester bond 5' to the abasic site in base excision repair. The kinetic parameters, K
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available