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Title: Evaluation of lead in meconium : a study on UK infants of South Asian origin
Author: Neelotpol, Sharmind
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2013
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Human exposure to lead, a persistent inorganic metal, can pose a significant risk to health and can arise from several sources e.g. lead-based paint, soil, dust, water pipes, and traditional cosmetics/remedies. A principal concern of lead exposure is for the foetus because without noticeable symptoms in the child lead can lower IQ, Standard Assessment Test (SATs) scores, and may increase the involvement in crime. The aim of this study was to evaluate lead exposure in South Asian infants. The hypothesis was that, living in the same environment, the South Asian 'mother-foetus unit' is more exposed to lead than white counterparts, because of their cultural orientation and lifestyle. To assess mothers' exposure to lead, a lifestyle questionnaire survey was compiled and completed by all participants (South Asians, n=98; white, n=38). Meconium (newborn's first stool) was chosen · as the biomatrix for measuring lead, because meconium accumulates throughout pregnancy and is likely to reflect the transfer of chemicals across the placenta. Matched samples of maternal antenatal blood and cord-blood were also collected with meconium to measure lead by Inductively Coupled Plasma-Mass Spectrometry. Measured lead concentrations in blood were below the current tolerable threshold of 5 I-Ig/dl. Significant differences were observed between participant groups in the lead levels in blood and meconium (p
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available