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Title: The Dysregulation of translation in neoplasia : the role of the translation initiation factor eIF4E and the 4E-binding proteins
Author: Millican-Slater, Rebecca Anne
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2013
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Breast cancer is a common disease with 49,961 new cases being diagnosed and causing 11,633 deaths in the UK in 2010. One of the cellular processes associated with carcinogenesis is dysregulation of translation. Translation is a tightly controlled process regulated by a number of different mechanisms, a key factor being the availability of eukaryotic initiation factor 4E (eIF4E). eIF4E has been shown to be overexpressed in a variety of human malignancies and higher levels of expression are associated with a poorer prognosis in some cancers. The availability of eIF4E is determined in a large part by the phosphorylation status of the 4E-binding proteins (4E-BPs). I have analysed the expression, localisation and prognostic importance of eIF4E and the 4E-BPs in large cohorts of both male breast cancer (MBC) and female breast cancer (FBC). I have also attempted to determine whether translation of the 4E-BPs is responsive to changes in eIF4E expression.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available