Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633579
Title: The effects of dietary probiotic administration on anxiety and cognition
Author: O'Hagan, Caroline
ISNI:       0000 0004 5346 9267
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2015
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Abstract:
This thesis explores the effects of dietary probiotic administration in anxiety-like behaviour and cognitive functioning. Desbonnet et al (2008) reported degradation of serotonin in the frontal cortex following dietary probiotic administration implicating cognition and anxiety-like behaviour. Therefore, the effects of direct serotonin manipulation on behaviour were examined in parallel to probiotic treatment. Identification of a task reliant on both frontal lobe and serotonergic functioning lead to the use of the probabilistic reversal learning task. Probiotic treatment did not produce effects on this task. Exploration of the effect of probiotic treatment on a watermaze reversal learning paradigm, known to be reliant on frontal lobe and hippocampal functioning indicated improvements with probiotic treatment. Further examination of this improvement in memory was explored in a novel object discrimination task and found to be significantly improved following probiotic treatment. These results produce clear indication the probiotic treatment improves aspects of learning and memory. The effects of dietary probiotics on anxiety-like behaviour were also explored. The results from the behavioural data indicated that these tests did not assess the same facet of emotional behaviour therefore conclusions could not be drawn on the effects of probiotic on anxiety-like behaviour. Examinations of the effects of probiotics at a cellular level were conducted through the use of H1 nuclear magnetic resonance spectroscopy. Results from this illustrate distinct alterations in the metabolite profile following probiotic treatment. The finding from this study provide a new rational for the further exploration of the effects of probiotic treatment on behaviour and cognition.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.633579  DOI: Not available
Keywords: BF Psychology
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