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Title: Investigating the antibacterial potency and spectrum of activity of the antibiotic thiomarinol
Author: Takebayashi, Yuiko
ISNI:       0000 0004 5366 5073
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2015
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Thiomarinol is a novel hybrid antibiotic produced by \(Pseudoalteromonas\) \(rava\) sp. nov. SANK 73390. It is structurally similar to a clinically significant antibiotic mupirocin, but includes an additional pyrrothine moiety joined to the mupirocin-like marinolic acid via an amide bond. Thiomarinol has been shown to be more potent against a wider range of microorganisms. This potency was hypothesised to be due to either an increase in inhibition of its target enzyme, isoleucyl-tRNA synthetase (IleS) or an increase in antibiotic uptake and/or inefficient efflux by bacterial cells or a combination of both. This thesis describes experiments that investigate the basis for this increase in potency.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QR Microbiology ; QR180 Immunology