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Title: Tropolone and sorbicillactone biosynthesis in fungi
Author: Fahad, Ahmed Al
ISNI:       0000 0004 5365 119X
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2014
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Stipitatic acid 12 is an aromatic seven-membered ring produced by Talaromyces stipitatus (previously known as Penicillium stipitatus). The identification of this secondary metabolite changed the concept of aromaticity and paved the way for the structural elucidation of many non-benzenoid aromatic natural products called tropolones. Stipitatic acid has undergone one of the most detailed isotopic labelling studies to understand how nature could form such an aromatic seven-membered ring under biological conditions. The incorporation of labelled acetate units into the carbon skeleton of stipitatic acid pointed to a polyketide origin for this fungal tropolonoid metabolite. Further labelling study using radioactive molecules of 3-methylocinaldehyde 29 suggested an oxidative ring expansion rearrangement for the formation of the tropolone seven-membered ring.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available