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Title: Comparative biology of foetal and adult mesenchymal stem cells
Author: Brady, Kyla
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2013
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Cartilage injuries and joint diseases such as osteoarthritis are a leading cause of pain and disability worldwide. Stem cell based tissue engineering applications have the potential to further our understanding of cartilage formation during development and degradation with disease progression. The regeneration of damaged articular cartilage relies on the identification of an appropriate cell source with a high proliferative propensity and consistent chondrogenic capacity. Mesenchymal stem cells (MSCs) are multi potent progenitors that can be stimulated to differentiate into musculoskeletal lineages including chondrocytes and are therefore particularly suited for cartilage repair strategies. Human first trimester foetal bone marrow derived MSCs have enhanced expansion potential compared to adult bone marrow derived MSCs and may represent an alternative cell source for cartilage development and disease modelling.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available