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Title: Epigenetically regulated gene expression in the dentate gyrus underlies stress-related cognition
Author: Saunderson, Emily Ann
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2013
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Psychological stress initiates a complex cascade within sparsely activated dentate gyrus granule neurons that is critical for learning processes and behavioral adaptation. Concurrent activation of the NMDA-R and GR results in activation of the ERK MAPK signaling cascade. This allows histone modifying enzymes in the nucleus to form a dual epigenetic modification on histone H3, phosphorylated serine 10 and acetylated lysine 14 (H3S10p-K14ac) at specific gene promoters. This is essential for induction of c-Fos and Egr-l gene expression and protein formation in activated DO granule neurons. Inhibiting various components of the ERK MAPK signaling cascade not only prevents formation ofH3S10p-K14ac and blocks c-Fos and Egr-l induction, but also inhibits the forced swimming-induced learned behavioural adaptation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available