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Title: Nutrient-mediated transcriptomes in the Paraventricular Nucleus of the Hypothalamus : dynamic regulation and downstream physiology
Author: Dearden, Laura Ann
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2013
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The obesity epidemic has fuelled research into the etiology of this complex disorder, including lifestyle, genetic vulnerability and more recently the in utero environment. Exposure to maternal obesity in utero programs metabolic dysfunction in offspring, however the mechanisms are unknown. Little is known about how the CNS senses, integrates and translates nutrient information into adjustment of neuronal and ultimately physiological function. The PVH is critical for maintaining energy- and glucosehomeostasis, but the molecular mechanisms underpinning this action remain unknown. We hypothesised that a PVH nutrient-sensitive transcriptome is critical in mediating adjustment of metabolic state, and that disruption of the PVH nutrient-mediated transcriptome may underpin physiological phenotypes in offspring exposed to an adverse in utero environment.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available