Use this URL to cite or link to this record in EThOS:
Title: Central and peripheral components of the human pressor response : effects of skeletal muscle training status and chronic heart failure
Author: Fisher, Wendy Jayne
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 1999
Availability of Full Text:
Access from EThOS:
During static muscular contraction, a rise in blood pressure and heart rate occurs which is known as the pressor response. This response is controlled by both central command and peripheral reflex components. The primary aim of this thesis was to examine the role of skeletal muscle training status on peripheral reflex inputs to the human pressor response. In addition, possible central adaptations to training were studied by comparison of responses to voluntary and evoked exercise at the same intensity. This has been achieved by measuring the pressor response to isometric exercise of the triceps surae, both in chronic anaerobically trained individuals, and following a short intense training program. In addition, the model of chronic heart failure has been used, in order to shed light on possible alterations in the mechanisms controlling the pressor response in this patient group. The relationship between muscle fatigue resistance and the pressor response was studied following the validation of a sub-maximal fatigue test, developed for use in less tolerant subject groups. The results demonstrate that in both chronic anaerobically trained individuals, and those undertaking a short training program, the pressor response is significantly reduced. The muscles of chronic heart failure patients also produce a significantly lower pressor response than in healthy aged matched controls. It is concluded that the afferent input from the muscle is adapted to repeated anaerobic conditions, in both the chronic trained and chronic heart failure patients. Furthermore, central as well as peripheral adaptation, is apparent following a short training program in healthy individuals.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available