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Title: Mitochondrial injury in the pathogenesis of acute necrotising pancreatitis
Author: Mukherjee, Rajarshi
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2012
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Introduction: Acute necrotizing pancreatitis remains a potentially devastating disease with a significant morbidity and mortality, but remains without specific drug therapy, Increasing evidence indicates that calcium overload leading to mitochondrial injury is central to pancreatic acinar cell fate, The mitochondrial permeability transition pore (MPTP) forms in response to cellular injury and determines cell fate, Cyclophilin-D (CyP-D) is a key regulator of MPTP formation, The role of the MPTP in pancreatitis is a novel area of investigation, This study explores the role of CyP-D and the MPTP in both murine and human isolated pancreatic acinar cell responses to pancreatic toxins as well as in the severity of murine experimental pancreatitis,
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available