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Title: An investigation into the relationship between the systemic inflammatory response and survival : a Glasgow Inflammation Outcome study
Author: Proctor, Michael J.
ISNI:       0000 0004 5355 4314
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2014
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Inflammation has been shown to play an integral role in a number of different disease processes. There is evidence that measurements of the systemic immune/inflammatory response are associated with mortality in patients with certain malignancies, as well as those with atherosclerotic disease. A variety of readily available inflammation-based prognostic scores, combining serum constituents of the systemic immune/inflammatory response, have been suggested for use in these patient groups. However, it is unclear whether systemic inflammation-based scores are universally associated with mortality across all tumour types and whether this relationship persists in atherosclerotic conditions including cardiovascular and cerebrovascular disease. The optimal constituents of such a score are also still to be determined. The present thesis further examines these topics with specific reference to: 1. The relationship between the presence of cancer, an inflammation-based prognostic score and biochemical parameters in a large group of unselected patients. 2. The relationship between an inflammation-based prognostic score and cancer survival in patients with malignancies at a number of different sites. 3. A comparison of commonly available inflammation-based prognostic scores in patients with cancer. 4. The prognostic value of a derived neutrophil to lymphocyte ratio, commonly available in patients with cancer undergoing chemotherapy. 5. The optimal serum constituents of the systemic inflammation-based Glasgow Prognostic Score (optimised) in patients with cancer. 6. The optimal constituents and prognostic value of a systemic inflammation-based score for predicting cardiovascular, cerebrovascular and all-cause mortality.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: RC0254 Neoplasms. Tumors. Oncology (including Cancer)