Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.629435
Title: Applications of the Dotz benzannulation reaction in natural product synthesis
Author: King, John D.
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 1991
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Abstract:
section I of this thesis contains a brief resume of the recent literature reports concerning the chemistry of Fischer Carbene Complexes. The latter part of the review discusses the mechanism of the Dotz benzannulation reaction. section II describes the author's own work, relating to the use of Fischer Carbene Complexes in organic synthesis. The main objectives of the research undertaken were to investigate the synthetic potential of the Shapiro/Dotz benzannulation sequence in natural product synthesis. Initial model studies involved the synthesis of 4-ethoxy-3-methoxy-2- (1' -methylethyl)- 5,6,7,8-tetrahydronaphth-l-ol and 3-methoxy-2-(1'- methylethyl)-5,6,7,8-tetrahydro-l,4-naphthoquinone from pentacarbonyl( ethoxycyclohex-l-enecarbene)-chromium (0) and 1- methoxy-3-methylbut-l-yne.pentacarbonyl(ethoxycyclohex-l-ene carbene)-chromium (0) was prepared by Shapiro chemistry from cyclohexanone 2,4,6-triisopropylbenzenesulphonyl hydrazone.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.629435  DOI: Not available
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