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Title: The effects of substitution of dietary saturated fatty acids with monounsaturated or n-6 polyunsaturated fatty acids on circulating endothelial and inflammatory markers of cardiovascular disease risk
Author: Altowaijri, Hana Abdulaziz
Awarding Body: University of Reading
Current Institution: University of Reading
Date of Award: 2013
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Endothelial dysfunction occurs in the early stages of the atherogenic process and contributes to the formation and progression of atherosclerotic plaques. Most of the classical CVD disease risk factors are associated with endothelial dysfunction. Circulating EPC have an important role in vascular repair and homeostasis. Increased numbers of MPs are associated with endothelial dysfunction. The DIVAS study (Dietary Intervention and VAScular function), aimed to determine whether substitution of SFA with MUF A or n-6 PUF A affects vascular function and other CVD risk factors such as markers of plasma lipids, inflammation including endothelial progenitor cells, endothelial microparticles and platelet microparticles. During the 3-years of this study which ran from 2010 until 2012, 202 subjects aged 21 - 60 were recruited in three cohorts. In a double blind, randomized parallel design study, subjects were assigned to one of three diets: I. SFA rich diet total fat 36% of energy (SFA 16%, MUFA 12% and n-6 PUFA 4%), 2. MUFA rich diet total fat 36% of energy (SFA 9%, MUFA 19% and n-6 PUFA 4%) and 3. n-6 PUFA rich diet total fat 36% of energy (SF A 9%, MUFA 13% and n-6 PUFA 10%). The MUFA rich diet significantly increased the numbers of circulating EPC. Both MUFA and n-6 PUFA decreased numbers of circulating EMP and PMP when replacing SFA in the diet. Regarding the inflammatory and endothelial markers were unaffected by the treatment on sP-selectin, v WF or NO. However, sE-selectin decreased significantly after consuming the MUFA rich diet, but not after the SF A or n-6 PUFA rich diets. MUF A has a beneficial effect on endothelial homeostasis, potentially promoting repair and maintenance and reducing endothelial damage by increasing circulating EPC and decreasing EMP, PMP and sE-selectin levels.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available