Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.628784
Title: The trapping of reactive intermediates using flow chemistry
Author: Henry, Cyril
ISNI:       0000 0004 5347 2028
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2014
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Abstract:
Flow chemistry, long established in the bulk chemical industry has recently received more attention in fine chemicals production and discovery chemistry with small-scale apparatus, resulting from laboratory equipment becoming commercially available. The interest in flow chemistry is driven in part by the precise control of reaction parameters, the automation and sequencing of reactions and facile access to certain areas of reaction space. The approach of flow chemistry is rather different to conventional batch chemistry. The dispersion of fluids and the thermic transfer were discussed. By taking advantage of working in a flow chemistry domain, the generation and trapping of ketenes from thermolysis of alkynyl ethers was developed. Kinetics and activation energy were determined by means of in-situ IR spectroscopy using conventional and improved methodologies. Generation of ketene such as methylene ketene, acyl ketene and vinyl ketene from dioxinone and Meldrum’s acid was also investigated under flow chemistry conditions. Coupled to a custom design of a photo-reactor, the flow apparatus was adapted to perform relevant synthesis of photochemical reaction such as [2+2] cycloaddition, arylation of alkene and SRN1 type reaction. Enabling better access to photochemistry, this photo-flow platform overcomes many limitations associated with batch reactors.
Supervisor: Whitby, Richard Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.628784  DOI: Not available
Keywords: QD Chemistry
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