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Title: Development and validation of novel autophagy biomarkers for malignant melanoma
Author: Ellis, Robert Alexander
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2013
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Cutaneous melanoma is an increasing health problem with an incidence that has steadily increased internationally in the last fifty years. When detected early, excision of the primary tumour is usually curative, however, metastatic disease remains extremely resistant to therapy and as yet, there is still no chemotherapeutic agent which offers a consistent effect on survival. Currently, the overriding prognostic indicator is disease stage defined at diagnosis, based on clinico-histological criteria including Breslow depth, mitotic rate and ulceration of the primary tumour; which combined, form the current American Joint Committee on Cancer (AJCC) Melanoma Staging and Classification system. However AJCC staging criteria alone are unable to identify the subset of patients with high risk early stage primary lesions that will eventually progress. The identification of credible biomarkers to refine the risk of disease progression, as well as predict those patients who would benefit from early stratified treatment is therefore fundamental to the enhancement of treatment efficacy-and the reduction in development of systemic disease.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available