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Title: Study of the roles of histone deacetylases in the regulation of platelet function
Author: Ali, Marfoua S.
Awarding Body: University of Reading
Current Institution: University of Reading
Date of Award: 2013
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Platelets play an essential role in haemostasis and thrombosis. Despite being anucleate, a growing body of evidence has established that platelets contain transcription factors. The identification of nuclear proteins within anucleate platelets suggests these proteins have complex functions. Histone deacetylases (HDACs) are examples of these proteins. 18 human HDACs have been identified, and are subdivided into 4 Classes, with Class III known as Sirtuins. Protein acetylation is known to play an essential role in the regulation of transcription in the nucleus which controlled by the acetyltransferase (HAT) enzymes and HDACs. Less is known about non-nuclear protein acetylation and its role in non-genomic cellular processes.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available