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Title: The role of cadherins and catenins in the segregation and migration of spinal motor neurons
Author: Bello, S. M.
Awarding Body: University College London (University of London)
Current Institution: University College London (University of London)
Date of Award: 2013
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During development Spinal motor neurons are generated from their point of origin in the ventricular zone and migrate to reach their final settling position (motor pools) in the ventral spinal cord. The formation of motor pools depends on early motor column segregation; cadherins cell adhesive proteins have been implicated in the segregation of motor neurons in the spinal cord but the exact role for these cell-cell adhesion molecules in the organisation and migration of spinal motor neurons during development is not established. I show that during development expression of cadherins contribute to the organisation and migration of spinal lateral motor column (LMC) motor neurons to their final settling positions and there is close association between spinal motor neuron and radial glia. Misexpression of a dominant negative cadherin results in abnormal migration of spinal motor neurons and columnar desegregation. Similarly, expression of a dominant negative catenin (a major cytoplasmic binding partner to cadherins) results in columnar desegregation and arrest of motor neuron along their migratory route. Perturbations of Wnt signalling have no effect on motor neurons migration indicating that the results are due to perturbation of cadherin adhesive function. Our observation that cadherin and catenins but not Wnt signalling contributes to normal migration and segregation of spinal motor neurons, suggest that cadherin may act in close association with radial glia in directing the migration of spinal motor neurons similar to the establish role of radial glia in cortical neuronal migration.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available