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Title: Expression of IGF-1 splice variants in women's reproductive system
Author: Cortes, E.
Awarding Body: University College London (University of London)
Current Institution: University College London (University of London)
Date of Award: 2013
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Studies in skeletal muscle following damage have demonstrated splicing of the insulin-like growth factor-1 gene to IGF-1Ea that is the source of mature IGF-I which is a main anabolic factor, IGF-1Eb,the function of which is not known and IGF-1Ec, known as Mechano Growth Factor (MGF). MGF increases the pool of muscle stem cells by activating them to proliferate. The aim of the thesis was to study expression of IGF-1 variants in female reproductive organs where cellular damage may lead to pathology: 1. The levator ani (LA) muscle: significant damage occurs following vaginal delivery and is a key element in pelvic floor physiology. LA samples from pre and post menopausal women were used as controls. 2. Ovarian tissue: repeated ovulations and failure of the epithelium to repair which may be a predisposing factor for ovarian cancer. 3. Myometrium: single monoclonal cellular damage may lead to abnormal proliferation of myometrium and may be a factor in the aetiology of uterine fibroids.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available