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Title: Angiogenesis and epithelial ovarian cancer : a study of vascular endothelial growth factor (VEGF) and associated factors in the pathogenesis and response to therapy of epithelial ovarian cancer
Author: Siddiqui, G.
Awarding Body: University College London (University of London)
Current Institution: University College London (University of London)
Date of Award: 2013
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In this thesis, I aim to explore the role of angiogenesis in epithelial ovarian cancer (EOC) and its correlation with risk of disease development, clinical outcome and disease response to platinum based chemotherapy. Immunohistochemical (IHC) techniques were used to examine the surgical specimens of 105 patients with primary EOC, FIGO stages I to IV. The results of vascular endothelial growth factor (VEGF) expression were correlated with clinicopathological variables and overall patient survival. No correlation between VEGF expression and clinicpathological factors was identified. However VEGF expression was found to significantly correlate with overall patient survival and a prognostic factor independent of the stage of the disease and residual tumour status (p< 0.0001). The association between VEGF-A expression in the tumour and the patient response to platinum based chemotherapy was examined by studying the expression of VEGF-A in 66 patients with advanced stage EOC (FIGO stages III-IV). Expression of the protein was correlated with platinum sensitivity and overall patient survival. I demonstrated that platinum resistant EOC was associated with a higher proportion of high VEGF expression in the tumour. To examine whether the differential production of VEGF is associated with the risk of EOC, I conducted a case control study to investigate whether the polymorphism in the VEGF gene – VEGF 1154 A/G genotype, which is known to be associated with the increased production of VEGF protein, is associated with the risk of EOC.There was a statistically significant difference in the distribution of the genotype of the VEGF 1154 A/G marker in the cases as compared with the controls. For the high-risk (GG) genotype, the difference between the patient and the control groups was statistically significant.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available