Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619147
Title: Underexploited (ipso, ortho) microbial arene dihydroxylation : uses in synthesis & catalysis
Author: Griffen, Julia Anne
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2013
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Abstract:
This thesis sought to expand upon the synthetic application of the underexploited ipso, ortho diene cis-diol microbial arene oxidation product from benzoic acid. The microbial oxidation of benzoic acid by mutant strains of bacteria to give the ipso, otho diene cis-diol may be considered to be a green and clean method. This biocatalytic route yields large quantities of an enantiopure chiral building block, which is not assessable via traditional synthetic methods. The fermentation product has seen application towards the synthesis of aminocylitols, which have been tested for their biological activity. Attempts to synthesise the fully oxygenated counterparts, cyclitols, were investigated. Expansion of previous work using a bromine substituted derivative led to a range of cross-coupled and iron co-ordinated products. Finally, a range of novel chiral acids and ketones were synthesised and evaluated for their catalytic activity towards asymmetric epoxidation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.619147  DOI: Not available
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