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Title: Vascular complications of obstructive sleep apnoea
Author: Mason , Rebecca Helen
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2013
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Obstructive sleep apnoea (OSA) is the third commonest respiratory condition after Asthma and COPD and has been increasingly linked to cardiovascular consequences. This thesis examines how OSA might affect different vascular beds; large (the aorta), medium (the carotid artery) and small (retinal and cerebral blood vessels) through five different studies. Each study will be reported as a separate chapter and a final discussion will assess the overall conclusions. Methodology Study one examines the prevalence of OSA in individuals with an abdominal aortic aneurysm and demonstrates the increased prevalence and rate of aneurysm expansion in those with severe OSA. Study two demonstrates the increased prevalence of OSA in individuals with type two diabetes and clinically significant diabetic macular oedema (CS MO). Study three examines the clinical benefit of continuous positive airway pressure (CPAP) in individuals with OSA and CS MO and demonstrates an improvement in visual acuity when CPAP is used for >2.5hrs per night. Study four is a retrospective examination of the effect of snoring on carotid vessel disease and shows no significant difference between the severity of snoring and degree of carotid artery stenosis. Study five describes the effect of minimally symptomatic obstructive sleep apnoea on cerebrovascular disease and shows no association between OSA and small white matter change but, does confirm the association of increasing age and hypertension. Discussion This thesis adds to our understanding of the association of OSA and vascular disease and the potential therapeutic benefits of CPAP in these individuals.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available