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Title: Regulation of agonist-induced Ca2+ oscillations by intraluminal Ca2+ : an experimental and theoretical study
Author: Hamilton, Benjamin Francis
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2013
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The ubiquity of Ca2+ signalling makes understanding its underlying processes vitally important. This thesis probes one part of that system, the regulation of agonist-induced Ca2+ oscillations, using both theoretical and experimental approaches. CHO–hOT cells transfected with human oxytocin receptors are used as the vehicle to assess the mechanisms underlying oxytocin-induced Ca2+ oscillations. The methodologies used to interrogate these oscillations are 1. varying the plasmalemmal Ca2+ entry and removal; 2. manipulating Ca2+ buffering within the endoplasmic reticulum (ER) and Ca2+ uptake into the ER lumen; and 3. constructing a mathematical model that replicates the experimentally observed phenomena.
Supervisor: Not available Sponsor: Biotechnology and Biological Sciences Research Council (Great Britain)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QA Mathematics ; QP Physiology