Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618752
Title: Actions of lipocortin-1 on the immune-hypothalamic-pituitary-adrenal axis
Author: Sudlow, Alan William
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 1994
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Abstract:
It is thought that the involvement of common mediators such as corticotrophin releasing hormone (CRR), cytokines, prostaglandins (PG's), pituitary peptides and glucocorticoids allows the integration of immune and neuroendocrine activity during the acute phase response (APR) to injury and infection. Glucocorticoids are the major inhibitory component within this complex system, which has been termed the immunehypothalamic- pituitary-adrenal (HPA) axis. In the past, lipocortin-1 (LC-1) has been implicated as a "second messenger" of glucocorticoid actions. The present study explored this potential role for LC-l in relation to the immune-HPA axis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.618752  DOI: Not available
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