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Title: The contribution of p50 and c-Rel in skin and ageing
Author: Fullard, Nicola
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2012
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NF-KB signalling is known to be involved in skin homeostasis, with aberrant expression within diseased skin. NF-KB has also been shown to be a key regulator of aged gene expression both within the skin and globally, being involved in ROS production, a key mediator of ageing, and interacting with sirtuins, expression of which is linked to longevity. The NF-KB family consists offive subunits, ReIA, ReIB, c-Rel, NF-KB 1 and NF- KB2 which act as both homo and heterodimers. They have distinct biological functions, however, the action of individual subunits remains largely unexplored. Immunohistochemical analysis of p50 (NF-KBI) and c-Rel subunits within sclerotic and psoriatic skin revealed abnormal expression patterns while previously published data associates SNPs in c-Rel with psoriasis and SNPs in NF-KB I with scleroderma.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available