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Title: Purine-based Inhibitors of Nek2 Kinase
Author: Wong, Christopher
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2010
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Protein kinases are involved in many important regulatory processes throughout the cell cycle. In particular, several kinase families (i.e. cyclin-dependent kinases, aurora, polo, Nek and checkpoint kinases) have been identified to play important roles in centrosome regulation and cell cycle progression. Consistent errors in cell duplication can often result in defective cells, possessing aneuploidy and/ or chromosome instability (CIN); a common trait of cancer cells. Overexpression and increased kinase activity is often observed in a diverse number of human cancers. Numerous drug discovery programs targeting CDKs, aurora, Polo and Chk kinases are currently ongoing, with evidence of anti-tumour activity observed by using selective, small molecule inhibitors.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available