Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607331
Title: Switchable charged surfaces to regulate bacterial adhesion
Author: Pranzetti, Alice
ISNI:       0000 0004 5363 6408
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2014
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Abstract:
The studies of biointerfaces, interfaces between synthetic materials and biological systems, such as bacteria, represent, by definition, a highly interdisciplinary field spanning across the disciplines of physics, materials science, engineering, chemistry, biology, bioinformatics and medicine. The main approach in biointerfacial science involves the preparation and characterisation of functional surfaces for specific interactions with bio-systems, and studies of the molecular and kinetic processes occurring at such interfaces, ranging from small molecules and biomolecular interactions, to cell and bacteria adhesion. Advanced material engineering techniques, such as self-assembly can structure surfaces that allow dynamic tuning of their properties (i.e. wettability and superficial charge). Recently, switchable surfaces able to undergo conformational switching in response to an applied external stimulus were shown to be suitable platforms for controlling cellular responses. In this context, the design and fabrication of a two-component electrical switchable SAM able to undergo conformational reorientation upon an applied electrical stimulus will be described. This dynamic platform will be used for the first time to gain new insights on the non-specific bacterial adhesion to surfaces in real-time.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.607331  DOI: Not available
Keywords: TP Chemical technology
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