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Title: Effect of fatty acids associated with dairy products on risk of cardiovascular disease
Author: Livingstone, Katherine Mary
Awarding Body: University of Reading
Current Institution: University of Reading
Date of Award: 2013
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Cardiovascular disease (CVD) and type II diabetes are the leading causes of morbidity and mortality worldwide. The impact of diet on novel, independent predictors of CVD, such as arterial stiffness, is of great interest. Findings from the Caerphilly Prospective Study, in which 2,512 men were followed up for up to 23- years, demonstrated a positive prospective association between saturated fatty acid (SFA) intake and arterial stiffness, while poly-unsaturated fatty acid (PUFA) intake was inversely associated. Furthermore, this cohort identified that dairy product intake (excluding butter) and milk were inversely associated with prospective arterial stiffness and systolic blood pressure (SSP) respectively. As milk was found to be cardio-protective, but SFA intake was associated with greater CVD risk, a study in dairy cows was designed to lower proportions of SFA in milk fat, with the aim of improving the ability of milk and dairy product consumption to reduce CVD risk further. This study identified that feeding dairy cows high proportions of maize silage (MS), as well as supplementation with extruded linseed, compared to non-supplemented, high grass silage (GS) diets, led to significantly lower proportions of milk SFA and higher proportions of monounsaturated fatty acids (MUFA) and PUFA in milk. A high SFA, low MUFA/PUFA dairy lipid, a low SFA, high MUFA/PUFA dairy lipid, and individual dairy FA were tested in an in vitro study using healthy and type II diabetic human aortic endothelial cells (HAEC) to determine possible beneficial effects of this strategy in relation to vascular function.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available