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Title: Development of a Pummerer-type cyclisation for an approach to ecteinascidin 597
Author: Nguyen, Trung Thanh
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2013
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A connective Pummerer-type cyclisation has been developed for an approach to the synthesis of ecteinascidin 597.Several electron rich glyoxamide substrates have been prepared and conditions for the connective Pummerer-type cyclisation have been developed successfully. In addition, the connective Pummerer-type cyclisation has been used with simple aldehyde substrates for the first time. The tetrahydroisoquinoline AB system of ecteinascidin 597 has been prepared successfully using the connective Pummerer-type cyclisation. The H ring has also been built. Several approaches for the synthesis of ecteinascidin 597 from the AB and ABH ring systems have been investigated.
Supervisor: Procter, David Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available