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Title: Tumour-mediated immunosuppression of antigen presenting cells: a potential target for cancer immunotherapy
Author: El Refaee, Mohamed
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2013
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Tumour escapes from immunosurvillence though tumour-mediated suppression. Tumour disrupts dendritic cells (DC) and macrophage functions and interferes with developing anti-tumour microenvironment. Indeed, DC dysfunction in cancer is a limiting factor in cancer immunotherapy. The hypothesis that alternation of DC MAPK pathway is a strategy by which tumours evade immunosurvillence was tested. Our results revealed that, tumours exploit DC through manipulation of ERK signalling pathway which resulting in inhibition of IL-12 production. In addition, tumours suppress the fibroblasts induced IL-23 production by DC. Through Interfering with IL- 12 and IL-23 production, tumours down regulate immediate inflammatory response responsible for defending against the newly developed malignancy. Similarly, our results on monocyte/ macrophage lineage showed that tumour alternate their function away from pro-inflammatory activity and closer to the regulatory profile.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available