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Title: Host innate response and virus-host cell interactions in avian influenza virus infection
Author: Perez, Belinda
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2013
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Highly pathogenic avian influenza (HP AI) H5Nl viruses cause devastating fatal disease in chickens, reaching nearly 100% mortality rate within 48 hours. In contrast, ducks show little or no clinical signs. This suggests that there are host species-specific differences in the innate immunity beMeen these two species. Large quantities of HP Al H5Nl viruses have been reported in skeletal muscle of infected chickens and ducks. An in vitro model comprising primary skeletal muscle cells from these two avian species was established to study host immune response 'to avian influenza. Infection with a low pathogenicity avian influenza (LP AI) virus in differentiated chicken muscle cells resulted in a vigorous induction of interferon-fJ and several interferon-inducible genes while two HP Al H5N 1 viruses effectively inhibited this antiviral response. Duck muscle cells did not appear to produce large amounts of type 1 interferons independent of the virus used.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available