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Title: Modelling effects of ionising radiation
Author: Siam, Fuaada Mohd
ISNI:       0000 0004 5359 7832
Awarding Body: University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 2014
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In this thesis, we are concerned with the molecular biology processes of ionising radiation (IR) damage and its repair. In particular, we develop a mechanistic model of high dose irradiation damage to DNA in mammalian cells by considering a population of cells structured by the number of double strand breaks and mis-repairs. This framework allows us to construct a mechanistic explanation for the Linear-Quadratic (LQ) formalism. Other contributions of this thesis are a model of ataxia telangiectasia mutated (ATM) dynamics in DNA damage repair, and a discussion of bistability, an important ingredient in the construction of a general theory of non-targeted radiation effects.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available