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Title: Investigating afferent mechanisms involved in bladder hypersensitivity
Author: Barki, Natasja
ISNI:       0000 0004 5358 9744
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2014
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This thesis investigates the afferent mechanism that may be involved in bladder hypersensitivity. The Study primarily focuses on the role of TRPM8 on bladder sensory firing. One part of the study also aims to replicate the ice water test in an in vitro mouse model to assess the contribution of TRPM8. An interesting aspect that the study investigates is the interaction between TRPM8 and TRPV1, TRPA1 and purinergic signalling. Finally, the study investigates ERβ KO mice as a model for interstitial cystitis. Investigating these parameters may reveal more information of the sensory changes that may occur in relation to bladder hypersensitivity, hence revealing novel targets for therapy.
Supervisor: Grundy, David Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available