Use this URL to cite or link to this record in EThOS:
Title: Rapid assembly of oligosaccharides : reactivity tuning of glycosyl fluorides
Author: Ince, S. J.
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 2000
Availability of Full Text:
Full text unavailable from EThOS.
Please contact the current institution’s library for further details.
Chapter 1 comprises a general introduction to the field of chemical carbohydrate synthesis. The work since 1984 that has had a profound influence on the development of 1,2-diacetal mediated reactivity tuning is summarised. Chapter 2 examines the applicability of 1,2-diacetal mediated reactivity tuning to oligosaccharides assembly. In particular, the use of the butanediacetal protecting group (BDA) to tune the reactivity of glycosyl fluorides is disclosed. The application of this methodology enabled the first one-pot assembly of a linear pentasaccharide from monosaccharide building blocks. Chapter 3 focuses on synthetic advances towards the Glysosylphosphatidylinositol (GPI) anchor of yeast Saccharomcyes cerevisiae I and analogues of the conserved GPI core structure. The synthesis the full carbohydrate core structure of I was completed by application of this new methodology. In addition, the development of a flexible strategy towards I enabled the examination of parallel routes to GPI analogues.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available