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Title: Mnemonic strategies in fronto-subcortical disorders : a neural systems approach
Author: Iddon, J. L.
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 1998
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This thesis is concerned with the cognitive and neural mechanisms of strategy generation and use in memory. The main hypotheses will be tested with neuropsychological analyses of performance on several tasks varying in the extent to which different types of strategy can be employed. The main hypothesis is that patients with frontal or fronto-subcortical dysfunction would exhibit specific deficits in the formulation and use of strategies for performing difficult and novel memory tasks, whereas patients with posterior cortical damage would not. Chapter 1 provides an introductory framework for the thesis. Chapter 2 outlines the methodology and statistical design for the thesis. Chapter 3 is a study of patients with frontal or temporal lobe excisions, young and old onset PD, and normal controls on a series of computerised tests taken from the CANTAB battery. Chapters 4 assesses the same patients as used in chapter 3 on a difficult and novel visuospatial problem solving memory task which requires a 'non-spontaneous' strategy to be 'realised', generated and implemented for successful completion of the task. Various manipulations of the same task have been developed in chapter 5 to distinguish the differential component processes involved in problem solving strategy processes, emphasising the importance of training. Chapter 6 demonstrates that the strategy deficit observed in these groups is not domain specific but also emerges on an analogous verbal memory task. It also demonstrates differences in fronto-striatal and posterior-cortical memory processes. Chapters 7 and 8 describe an assessment of two further patient groups. Chapter 7 is an examination of congenital hydrocephalus patients on tests from the CANTAB battery and the two strategy tasks, showing that this group follows a similar pattern of impairments to patients with frontal or striatal damage. Chapter 8 shows that schizophrenic patients on the two different types of mnemonic strategy tasks exhibit a less specific pattern of impairment, further implicating both fronto-striatal and temporal lobe structures in the neuropathology of this disorder.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available