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Title: Effect of weekly iron supplementation and antihelminthic treatment on the physical growth and development of Bangladeshi children
Author: Husain, M. M.
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 2003
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The study was conducted in a slum area of Dhaka, the capital of Bangladesh and involved a double-blind randomised trial of 24 weeks duration with three intervention groups and a control. The three intervention groups comprised an iron only group (Fe), and iron and chemotherapy group (Fe+Ch) and a chemotherapy (Ch) group. The iron groups received tablets, which contained 120-mg elemental iron and 400mg folate on a weekly basis, while the chemotherapy and control received weekly placebo tablets of similar appearance. The chemotherapy groups were treated with albendazole at the beginning of the study and at 12 weeks and the other two groups received placebos. The main objectives were to determine the impact of weekly iron supplementation on haemoglobin and anaemic status; to assess the impact of three-monthly chemotherapy on the prevalence and intensity of infection of three common intestinal parasites; to determine whether the combination of weekly iron supplementation and regular deworming impacted on haemoglobin levels and anaemic status compared with groups of children receiving either iron supplementation only or chemotherapy only; and to test whether the three interventions resulted in improved growth (as measured by changes in height, weight and z-scores of height-for-age, weight-for-age and weight-for-height) in comparison with the control group. There were significant improvements in the haemoglobin concentration in the Chemotherapy (Ch) group, while the prevalence of anaemia declined significantly in all groups. Significant declines in prevalence of Ascaris, Hookworm and Trichuris in the chemotherapy treated groups (Ch and Fe+Ch, Fe<2+Ch and Fe³2+Ch) were observed. Also significant reductions in intensity of Ascaris, Hookworm and Trichuris were found in the chemotherapy treated groups. As expected, there were significant increases in all groups in height and weight but no significant differences in the absolute or relative changes between groups.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available