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Title: Cognitive pattern and progression in cognitive variant of multiple sclerosis
Author: Grew, Tracey
Awarding Body: University of London
Current Institution: Royal Holloway, University of London
Date of Award: 2013
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Multiple sclerosis (MS) is a progressive disease of the central nervous system and cognitive impairments are prevalent in a large proportion of patients. A subpopulation of atypical MS patients has been highlighted who present with cognitive dysfunction as their most predominant symptomology, with moderate motor or sensory deficits. A study by Merrett and colleagues (2011) documented the neurocognitive profile of a group of atypical patients (termed 'Cognitive-MS'), and compared it to a typically presenting (Typical-MS) group. It was found that patients with Cognitive MS displayed more severe cognitive impairments relative to the Typical-MS group, and a control group. Furthermore, the Cognitive-MS group demonstrated a wider array of impairments, revealing cognitive deficits commonly seen in MS, as well as some considered rare. The current study was in two parts, comprising an extension and follow-up to the previous study by Merrett and colleagues (2011). Initially, the study was interested in whether the differences in cognitive performance between the Typical-MS and Cognitive-MS groups remained after increasing the sample size. Secondly, the study aimed to investigate the extent and nature of longitudinal cognitive change within both groups after a two-year period.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.Clin.Psy.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available