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Title: Brief international cognitive assessment for multiple sclerosis (BICAMS) : UK validation
Author: Orchard, Alex
Awarding Body: University of London
Current Institution: Royal Holloway, University of London
Date of Award: 2013
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Multiple Sclerosis (MS) is an autoimmune disease of the Central Nervous System. Cognitive impairment occurs in a significant proportion of cases and has a detrimental impact on quality of life and everyday functioning. Despite evidence of the impact of cognitive deficits and the improvements people can make with awareness of their condition, cognitive assessment Is not widely available outside specialist centres. Recently a consensus panel identified a short battery of cognitive assessments, which could be used to assess cognition in research and clinical settings (Brief International Cognitive Assessment of Multiple Sclerosis, BICAMS). One measure from this battery was suggested as a short screening tool (Symbol Digit Modalities Test, SDMT). These tests are a subset of a longer assessment widely used in MS research with established sensitivity and specificity, Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS). Recommendations were made for cross-cultural validations to aid calibration and Interpretation of results. The current study seeks to establish whether BICAMS and SDMT are sensitive measures of cognitive impairment In a UK MS outpatient population. Matched groups of people with MS and Controls were compared on MACFIMS and a range of factors known to affect performance on neuropsychological assessments. Participants with MS achieved significantly lower scores than matched Controls on SDMT and BICAMS measures. The impacts of depression and fatigue were considered. Significantly more participants with MS were identified as cognitively impaired by both measures. Cognitive impairment classification on both measures was compared with MACFIMS classification. There were no Significant differences between the proportions of participants identified as impaired on BICAMS or SDMT compared to MACFIMS. Sensitivity, specificity and accuracy reached acceptable levels for SDMT; specificity and accuracy reached acceptable levels for BICAMS. This study provides preliminary evidence that BICAMS and SDMT could provide qUicker, more accessible assessment of cognitive dysfunction in MS.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (D.Clin.Psy.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available