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Title: Pathogenesis of Mycoplasma bovis pneumonia in calves
Author: Wrigley , Karina Mary
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2013
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This project investigated the pathogenic mechanisms involved in the development of M. bovis pneumonia, and examined the contribution of the host's immune response. Four experiments investigated the response of calves to different M. bovis vaccination protocols. In addition several immunological parameters were measured, and attempts were made to relate these to pathology. One study described in Chapter four demonstrated that priming the immune system with a hydrophobic M bovis extract foreshortened the advent of clinical disease and induced more severe pathology. In contrast, results of a second experiment described in Chapter 5 suggested that vaccination with a hydrophilic M. bovis extract neither provided protection nor enhanced disease. Experimental infections described in Chapters 3 and 6 produced more ambiguous results. This was possibly due to pre-existing infection in the calves at the time of challenge, or to natural variation in the immune response between calves. Overall, results of the four studies demonstrated the deleterious involvement of the host's immune response in the development of pathology, and suggested that it is membrane lipoproteins, which stimulate this deleterious immune response. In none of the experiments could the peripheral immune response be correlated with pathology, and no difference in peripheral immune pa ~meters was detected between calves with different degrees of pathology. A fifth study investigated the correlation between the expression of certain membrane vsp and lung pathology. Results demonstrated evidence of variation in expression of vsp, and suggested that this variation is random and not correlated with pathology. The last study examined the local immune response. Results suggested that both the innate and the acquired immune response participate in the development of M. bovis lesions, and indicated a role for CD4, CD8, y5 T cells and B cells in the pathogenesis of M. bovis pneumonia in calves.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available