Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603563
Title: Design, manufacture and characterisation of hot-melt extruded drug delivery platforms
Author: Williams , Marcia Angela
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2013
Availability of Full Text:
Full text unavailable from EThOS. Thesis embargoed until 31 Dec 2017
Abstract:
Hot melt extrusion (HME) is a preferred technique for preparing solid dispersions of poorly water soluble drugs, for the enhancement of drug dissolution rate and ultimately bioavailability. This technique is preferred to other methods due to the short time necessary for processing, and no need for solvents, which can be both problematic to patients and the environment. A wide variety of carriers is available, and may be selected based on factors such as the nature of release required and the compatibility with the drug. In this thesis, solid dispersions of two model BCS class 11 drugs, felodipine and celecoxib were prepared using Polyvinylpyrrolidone (PVP), EudragitSl L- IOO (LJOO) and Eudragit~ FS 30D (FS30D) by HME. The influence of molecular weight on the ability of the PVP to form a one phase amorphous dispersion and to stabilize the dispersed amorphous drug was investigated. Also, the feasibility of using the Eudragit polymers as both single and binary matrices for the generation of one-phase solid dispersions via ID1E, and to stabilize the amorphous drug during storage and dissolution was investigated. Pluronic Fl27 (FI27) was added to best performing binary and ternary systems to investigate the influence of surfactant on stability and dissolution. No difference was observed in the ability the different molecular PVP to form a one-phase molecular dispersion with felodipine or celecoxib and in stabilizing the amorphous form. The ability of methacrylate polymers to improve the pharmaceutical performance of the solid dispersions was dependent on drug loading. Also the performance of the binary methacrylate matrices depended on the ratio of the polymers. F127 improved the degree of supersaturation, and its effect on stabilization of the amorphous drug was concentrated dependent, with higher levels producing instability. The best performing formulation was the ternary system consisting of the higher ratio of FS30D with 10% F 127.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.603563  DOI: Not available
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