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Title: Cellular responses to modulated radiation fields
Author: Trainor , Colman Joseph
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2013
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The primary aim of radiotherapy is to deliver sufficient doses in order to eradicate a tumour whilst sparing damage to normal tissue. Advanced radiotherapy techniques such as Intensity modulated radiation therapy (IMRT) have been developed that aspire to improve the conformity of beam delivery in order to improve tumour control and reduce normal tissue complications. It is of vital importance to determine the response to modulated fields within the directly targeted and out-of-field regions and to gain greater understanding of the mechanisms driving the response, This work investigates the cell survival and DNA damage responses following modulated radiation field delivery. It has shown that significant decreases in cell survival occur within regions outside the radiation field following the delivery of modulated radiation. It has demonstrated for the first time the spatial and temporal characteristics of DNA damage and repair across a modulated radiation fie ld. Initial and residual DNA damage was shown to increase within out-of-field regions following modulated radiation field delivery. The bystander effects were observed to occur independently of several parameters such as dose-rate, hypoxia and dose fractionation. It can be concluded that intercellular communication between populations ill- and out-of-field is pivotal for the induction of out-of-field cellular responses that may need to be considered further as potential effectors of clinical outcome.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available