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Title: Polymeric microneedle-mediated transdermal drug delivery : application to paediatric dosing
Author: Tuan Mahmood, Tuan Mazlelaa
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2013
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Full text unavailable from EThOS. Thesis embargoed until 01 Dec 2018
Development of formulations and drug delivery strategies for paediatrics use is scientifically challenging due the broad age ranges presented within this population, resulting in varying requirements in achieving optimised patient outcomes. Though the oral route of drug delivery remains the preferred option for patients due to its convenience, there are a number of problematic issues such as difficulty in swallowing and palatability of the oral medicine that are specific to this population. On the other hand, parenteral route of drug administration is not well accepted in this population due to needle-related fear and pain. For these reasons, a plethora of alternative routes of drug administration have been investigated. One of such approaches is via transdermal route. The readily accessible and large surface area of the skin provides a promising site for delivery of drugs into the body. However, the stratum corneum (SC) offers a formidable barrier to transdermal transport due to its lipophilicity and highly complex cellular architecture. Microneedle (MN) delivery has been proposed as a strategy to breach the SC barrier function in order to facilitate effective transport of molecules across the skin. This strategy involves the use of micron-sized needles fabricated from different materials and using different geometries to create transient aqueous conduits across the skin. In this present study, . poly(methyl vinyl ether/maleic acid) (PMVE/MA)-based polymeric MNs, namely soluble MN and hydrogel forming MN, were fabricated using a micromoulding technique and incorporating two model drugs commonly used in paediatric patients, i.e. caffeine and lidocaine hydochloride. The feasibility and efficacy of these MNs for potential paediatric dosing were investigated in a series of in vitro and in vivo studies, by employing. The views pertaining MN technology were sought among school children in Northern Ireland (via focus groups discussion), members of UK general public and UK paediatrician (through online surveys), in order to determine the perceived perceptions, acceptance, barriers and concerns for future adoption of this technology. In this thesis, polymeric MNs have been shown to dramatically enhance the skin permeability of the model therapeutic molecules either in vitro or in vivo. Furthermore, this thesis also highlighted a large consensus on the opinions of MN technology among schoolchildren, UK paediatricians and the general public, with respect to its potential usefulness of delivering various types of therapeutic substances for the benefit of paediatric population
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available