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Title: EEG-fMRI signatures of spontaneous brain activity in healthy volunteers and epilepsy patients
Author: Laufs, H.
ISNI:       0000 0004 5354 3391
Awarding Body: University College London (University of London)
Current Institution: University College London (University of London)
Date of Award: 2014
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Background: Functional magnetic resonance imaging (fMRI) provides maps of haemodynamic activity with uniform resolution across the brain. Simultaneous recording of electroencephalography (EEG) during fMRI (EEG-fMRI) was developed to localize spontaneously occurring epileptiform discharges. In focal epilepsy, it can identify candidate brain regions for surgical removal as a treatment option in medically refractory epilepsy; and in generalized epilepsy syndromes reveals those involved during the EEG changes. In healthy subjects, EEG-fMRI has linked spontaneous ongoing EEG activity with fMRI resting state networks. Methods: After method refinements, patients with medically refractory focal epilepsy and those with generalized epilepsy were studied with EEG-fMRI and group analyses performed to identify typical sets of brain regions involved in the epileptic process. Findings: In individual patients with refractory focal epilepsy, EEG-fMRI can produce activity maps including the seizure onset zone and propagated epileptic activity. Clinically, these can be confirmatory of results from alternative diagnostic techniques, or alternatively serve to generate a hypothesis on the potential epileptic focus, but under certain conditions may also be of negative predictive value with respect to surgical treatment success. At the group level in patients with temporal lobe epilepsy and complex partial seizures as well as in patients with generalized epilepsy and absence seizures, altered resting state network activity during EEG changes were found in default mode brain regions fitting well the ictal semiology, because these are known to reduce their activity during states of reduced consciousness. In (1) lateralized temporal lobe epilepsies, (2) an unselected mix of focal epilepsies, and (3) generalized epilepsies, activity increases occurred in typical brain regions suggesting an associated “hub function”, namely ipsilateral to the presumed cortical focus in the hippocampus; in an area near the frontal piriform cortex; and bilaterally in the thalamus, respectively. These findings argue for a network rather than a zone concept of epilepsy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available