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Title: A proof of concept study of epigenetics as a marker of neuropsychiatric symptoms in Parkinson's disease
Author: Moore, Kerry
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2013
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Awareness of the negative effect of non-motor symptoms (NMS) on quality of life in idiopathic Parkinson's disease (PD) has increased in recent years. The greatest degree of variation in the symptomatology in PD involves NMS, but the source of this susceptibility remains undetermined. The aetiology of NMS is likely to be multifactoria1 and involve neurochemical~ neuroanatomical, pharmacological and psychological explanations. Several symptoms may have a genetic basis - revealed within, or exposed by, the neurodegenerated milieu of the Parkinson's brain, akin to the processes that appear to operate in Alzheimer's disease. The comparatively unexplored area of epigenetics is also considered to be a potential cause of both PD and the neuropsychiatric symptoms that can accompany it. This study helps explain the biological mechanisms underlying PO development by exploring genetic and epigenetic profiles using a case-control approach. Elucidating the (epi)genetic determinants and consequences for common diseases such as PO can help inform personal and public strategies for minimising disease and optimising treatment.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available