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Title: Palladium and copper mediated cross couplings using dialkylphosphites
Author: Fraser, Jamie
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2013
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Described herein are synthetic methodologies using palladium- and copper-mediated cross coupling reactions involving dialkylphosphites. Chapter 1 discloses two methods for producing alknylphophonates. The first is a novel palladium mediated cross coupling of alkynylbromides with dialkylphosphites. The second is an improvement of a known aerobic copper mediated cross coupling using terminal alkynes and dialkylphosphites. Chapter 2 discloses a novel aerobic copper mediated amide synthesis method. Chapter 3 discloses a novel aerobic copper mediated phosphoramidate synthesis method. All of the above developed methodologies were found to produce their respective products in acceptable yields and tolerate a wide range of functionality. The experimental section comprises the practical methods for effecting the above reactions and the experimental data for all of the compounds presented herein.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available