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Title: Genetic and dietary models of insulin resistance : effects on tissue specific gene expression
Author: Pearson, Samantha
Awarding Body: University of Buckingham
Current Institution: University of Buckingham
Date of Award: 1997
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Insulin resistance is a common fmding in many disease states such as impaired glucose tolerance/diabetes mellirus, acanthosis nigricans, polycystic ovarian syndrome, precocious pseudo-puberty, Syndrome X and obesity. Hypertensive subjects have been shown to be insulin resistant but the relationship between hypertension and insulin resistance still remains to be clarified. Studies were undertaken to investigate the possible cause and effect relationship between insulin resistance and hypertension in a non-obese genetic rodent model of hypertension, the Spontaneously Hypertensive (SH) rat. Skeletal muscle and adipose tissue are the major insulin sensitive tissues with respect to glucose utilisation with skeletal muscle being quantitatively the most important. Soleus muscle and adipocytes were isolated from SH, Wistar Kyoto 0NKY) and Wistar rats at 3, 5 and 18 weeks of age. Muscle and adipocyte preparations were incubated in the presence of radiolabelled glucose in order to assess the sensitivity of individual tissues to insulin· stimulated glycogen synthesis and insulin·stimulated lipogenesis respectively. At 3 weeks of age the soleus muscle of SH and WKY rats were less sensitive to insulin than Wistar controls. This effect is present prior to the 6nset of hypertension and points to muscle insulin resistance being part of the genetic background of both the SH and WRY rats. It is unlikely therefore that the decreased sensitivity of the soleus muscle is directly involved in the aetiology of hypertension in SH rats.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available