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Title: Studies on peptidergic modulation of insulin secretion
Author: Nolan, Anna L.
Awarding Body: University of Buckingham
Current Institution: University of Buckingham
Date of Award: 2001
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Control of glucose homeostasis is modulated by the secretion of insulin from the pancreatic islets of Langerhans. A large number of peptides regulate this secretion exerting effects not only on islets of Langerhans but on other tissues in an organism. The work presented here describes the action of a number of natural and synthetic peptide analogues on insulin secretion. Firstly, analogues of somatostatin were obtained to provide somatostatin receptor subtype selective ligands to elucidate the receptor subtype responsible for mediating the, effects on insulin secretion in isolated rat islets.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available