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Title: Regulation of Beta-cell tropin secretion from intermediate pituitary of lean and obese mice
Author: Eagle, Laurence Alfanso
Awarding Body: University of Buckingham
Current Institution: University of Buckingham
Date of Award: 1993
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B-cell tropin (BCT) is a pro-opiomelanocortin-derived peptide which is released from the pituitary neurointermediate lobe (NIL) of rodents and other mammals. It has been shown to act as a potent insulin secretagogue, has lipogenic properties both in vitro and in vivo, and its sequence has been characterized as corresponding to ACTH22-39. Perifusate of NIL can be fractionated by reverse phase HPLC into two peaks, one containing CLIP (ACTH 18-39) -related, and the other BCT-related material. BCT levels have been found to be elevated in various obese/diabetic animal models, and this, coupled with the peptide's lipogenic properties, suggests that it may have a role in the obesity commonly associated with the human disease, type II diabetes. The aim of the work described in this thesis was to assess the factors controlling the release of BCT from the pituitary in the normal and obese diabetic state. The obese (oblob) mouse and its lean (+/+) counterpart were used as the animal models for these metabolic conditions.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available