Use this URL to cite or link to this record in EThOS: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601357
Title: Aspects of the physiology and pathophysiology of the hormone Beta-cell tropin
Author: Davenport, Michelle
Awarding Body: University of Buckingham
Current Institution: University of Buckingham
Date of Award: 1993
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Abstract:
Beta-cell tropin (BCT) is a pro-opiomelanocortin-derived peptide which is released from the pituitary neurointennediate lobe (NIL) of rodents and other mammals. It has been shown to act as a potent insulin secretogogue, has lipogenic properties both in vivo and in vitro, and its sequence has been characterised as ACTH22•39• BCT levels have been found to be elevated in various obese/diabetic animal models, and human type II diabetes. This suggests that the peptide may have a role in the development and maintenance of the obese and diabetic states. The aim of the work described in this thesis was to characterise the mechanism of action of BCT on lipogenesis in white and brown adipose tissue, and to determine whether the hormone has a role in the pathological changes which occur during the development of dietary induced or genetic obesity. or the physiological adaptations in adipose tissue metabolism which are associated with pregnancy and lactation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.601357  DOI: Not available
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