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Title: Prognostic factors in paraproteinaemia, treatment of multiple myeloma
Author: Al-Rubei, Kastal J.
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 1980
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Ninety-two patients with multiple myeloma were treated with varying cytotoxic regimens. The patients were classified into different groups according to the therapy they received. The prognostic significance of Albumin, Haemoglobin, Serum Urea, and corrected Calcium were studied in each group. From this rather small series', serum urea appears to be the most important prognostic factor. The patients were also studied according to their tumour mass. They were classified into a High (1.2 x 1012 cells/m2), Intermediate (0.6-1.2 x 10'2 cells/m2) and Low (0.6 x 1012 cells/m2) tumour mass groups according to the method used by Alexanian (1977). There was no difference between the three groups. The rate of paraprotein response bore no relationship to prognosis but. there was a significant correlation between the degree of paraprotein response and survival. The B- lymphocytes with idiotypic structure were studied before and after treatment in two patients with multiple myeloma. The percentage of these cells decreased once the patients went into remission.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available